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Most patients report minimal discomfort during the treatment

Do not restart if you experienced a severe hypersensitivity reaction (anaphylaxis, angioedema) during your previous course of semaglutide

Fatigue from retatrutide is a documented concern

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However, if dose escalation triggers nausea that lasts longer than your initial adjustment period, your provider may recommend a slower titration schedule or a switch to a different semaglutide formulation