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Key translational challenges include optimizing dosing strategies to balance physiological and pathological ROS signaling, identifying appropriate therapeutic windows during the injuryrepair continuum, and achieving effective tissue-specific delivery to the supraspinatus muscle
Several transition metal ions can catalyze Fenton and Fenton-like reactions to produce hydroxyl radicals (OH) and kill cancer cells in the TME
For best outcomes, most patients undergo 48 sessions, spaced weekly or bi-weekly
This reduces inflammation
10.1046/j.1468-1331.2002.00384.x Eur
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