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By activating AMPK, MOTS-c forces the body to switch from storing fat to burning it for fuel, while simultaneously making cells more sensitive to insulin
Doses used clinically generally start modestly and can be adjusted upward based on the patient, with the intravenous route favored precisely because it sidesteps the oral-absorption question
Brightens tone, minimises pores, and reinforces the skin barrier
Nature Medicine, 2015