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The tradeoff is that higher doses require substantial volumes, and a full 2.4mg maintenance dose would require nearly 1.44ml, which exceeds the capacity of a standard 1ml insulin syringe
Understanding this broadens the perspective
This produces a feeling of fullness that can tip into nausea, especially after eating too much or too quickly
10-13 In subsequent trials where higher doses of the GLP-1/GIP agonists were used in non-diabetic obese subjects, weight loss of 15% to 21% of body weight was seen
Some patients are candidates for one and not the other, and a physician sorts that out with your history and labs
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