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CD8 + cytotoxic T lymphocytes, reactive to TPO and Tg, promote glandular destruction, aided by increased ICAM-1 expression on follicular cells and elevated serum levels of VCAM-1 and TIMP-1

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Cytosolic double-stranded DNA as a damage-associated molecular pattern induces the inflammatory response in rat pancreatic stellate cells: a plausible mechanism for tissue injury-associated pancreatitis

Additionally, aging also alters the immune system, which is subsequently leading to inflammaging

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Fujiwara, C