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Menopause Diet: Key Concepts and Nutritional Needs The hormonal upheaval during menopause, particularly the decline in estrogen, can increase the risk of osteoporosis, cardiovascular disease, and altered metabolic states

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secondly, relative to other organs, the brain has lower levels of ROS scavenging enzymes and thirdly the brain is 60% fat a high proportion of which is unsaturated fatty acids that are highly susceptible to lipid peroxidation

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The observation that DNA methylation can account for rather more of the variance in serum UA than genetic polymorphisms 32 indicates the strong potential of investigation into this and other epigenetic factors in relation to risk of PD and, of course, other disorders associated with UA