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This makes combination therapy more effective and improves health outcomes

doi: 10.36899/JAPS.2020.2.0051 13 AuthaidaS.RatchamakR.BoonkumW.ChankitisakulV

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The nanoparticles of silibinin exhibited antioxidant effects against intracellular oxidative stress by upregulating the Nrf2/ARE pathway, reducing ROS, modulating antioxidant enzyme responsiveness, and inhibiting downstream pathways of mitochondrial damage (Ding et al., 2022)

10.3389/fmolb.2022.1080140 70 MilhelmZ.ZanoagaO.PopL.IovitaA.ChiroiP.HarangusA.et al (2025)

Moreover, the combined treatment of these two agents proved more effective than single interventions, suggesting potential synergistic effects (Mobasher et al., 2022)