They can help generate hypotheses and guide more rigorous, controlled research that allows us to draw more definitive conclusions.
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Furthermore, downstream metabolites of plasma PNKP, especially the easily detectable glutamate to pyruvate ratio, may serve as biomarkers for monitoring treatment efficacy, enabling personalized management by assessing patient response to therapy
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In the HepG2 fatty liver cell model, hypoxia-inducible factor-2alpha (HIF-2)/PPAR pathway was found to be essential for Lira to inhibit liver lipid synthesis and reduce lipid-induced hepatic steatosis [57]
Pettegrew JW, Klunk WE, Panchalingam K, et al