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No, there is no clinical evidence supporting routine digestive enzyme supplementation with GLP-1 receptor agonists

These pills work on the same GLP-1 pathway but use different active ingredients

One way in which semaglutide GLP-1 may impact metabolism is by enhancing insulin secretion and sensitivity, which can improve the bodys ability to process carbohydrates and regulate blood glucose levels

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Genetic factors influencing glucagon-like peptide-1 receptor sensitivity and glucose metabolism may affect both tolerability and therapeutic benefit over time