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GLP-1 medications are generally prescribed for adults with obesity (BMI 30) or those who are overweight (BMI 27) with related health conditions such as type 2 diabetes, high blood pressure, or high cholesterol

Nlrp3 activation causes spontaneous inflammation and fibrosis that mimics human NASH

There is no confirmed release date for routine clinical prescribing

Some patients experience constipation or reduced appetite while taking semaglutide, which can limit overall nutrient intake

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When tested in obese cynomolgus monkeys, treatment with AT-7687 in combination with liraglutide results in lower total energy intake and significant body weight loss compared to placebo but no differences when compared to liraglutide alone