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The foundational characterization appeared in European Journal of Endocrinology in 1998, reporting selective agonism of the growth hormone secretagogue receptor type 1a (GHS-R1a) without significant elevation of ACTH, cortisol, prolactin, FSH, LH, or TSH, even at doses 200-fold above the GH-releasing ED50 in preclinical models

It measures a 50% reduction in tender and swollen joint counts, plus 50% improvement in 3 of 5 related criteria

Notably, CNS GIPR antagonism produces body weight loss in obese mice and also extends the anorectic effect of a GLP-1R agonist

Brand-name GLP-1 medications are also available if covered by insurance

Without vitamin C, glutathione would get depleted quickly and couldnt keep protecting your cells as effectively