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Yet, for others, levels barely improve

Additionally, impaired leptin regulation in the liver disrupts satiety signals, driving overeating and creating a vicious cycle

Methods: 25 women with PCOS and obesity, aged 33.7 5.3 years (mean SD), were treated with once-weekly subcutaneous semaglutide 1.0 mg as an adjunct to metformin 2000 mg/day and lifestyle intervention for 16 weeks

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Morrish DW et al

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