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Datta, D

3.2.2 Downregulate expressions of cyclooxygenase-2 and inducible nitric oxide synthase Overexpression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) are correlated to colorectal carcinogenesis, and inhibition of their activities leads to cancer prevention ( 3.2.3 Downregulate expression of NF-B and upregulate expression of Nrf-2 NF-B regulated inflammatory responses and its activation lead to increased expression of pro-inflammatory cytokines, while nuclear factor-erythroid 2related factor 2 (Nrf-2) reduced the synthesis of inflammatory mediators by inhibiting the NF-B (Figure 2)

Administration Technique: Ensure proper injection technique to avoid local irritation or discomfort

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An interesting finding of this study is that aging mice and Klotho-deficient mice share abnormally higher levels of oxidative stress (Figures 3 and 7

Small molecule photocatalysis enables drug target identification via energy transfer