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The weighted incidence of suicidality was 4.3 and 4.6 for every 1,000 person-years in individuals prescribed GLP-1 receptor agonists and SGLT-2 inhibitors, respectively

Regular clinical review should include: Assessment of weight loss trajectory and nutritional status Evaluation of fall risk, particularly in older adults Review of concomitant medications affecting bone health Monitoring for new fractures or bone pain When to seek medical advice : Patients should contact their GP if they experience unexplained bone pain, height loss, new fractures from minimal trauma, or concerns about rapid weight loss

Understanding how PDA compares helps researchers select the right tool for their specific needs

Others: Roche, J&J, Sanofi, and AZ have had GLP-1 efforts (some deprioritized) or new dual/triple agonists in development (e.g., Roches pipeline includes a dual agonist announced in 2024)

body mass index (BMI) of 21.033.0 kg/m 2 , sedentary lifestyle (defined by Stanford questionnaire, Additional file 1: Table S1), maintain current dietary habits and activity levels, if taking supplements agree to maintain dosing regimen for at least one month prior to baseline and during the study, agree not to start any new supplements, give voluntary, written informed consent to participate

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