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Why Tirzepatide and Not Pure GLP-1 What Ive discussed so far is the evidence for GLP-1 medications

Consistent with these findings, it has been demonstrated that the GLP-1R agonist Ex-4 (Ronnekleiv et al., 2014) excites ARC POMC neurons in mice

By improving insulin production, minimizing glucagon secretion, and impacting areas in the brain that control appetite, semaglutide can help reduce hunger and promote feelings of fullness

That drop is part of why skin gets thinner, wounds heal slower, and connective tissues lose resilience as we age

14 Additionally, it has also been suggested that GLP-1 RAs may independently improve endothelial and platelet function and could also have direct neuroprotective effects

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