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These genes usually participate in intestinal immunity, the nuclear factor B (NF-B) signaling pathway, cytochrome P450 metabolism and melanoma formation.34 It has been confirmed that aloe leaves can inhibit CYP3A and CYP2D6 expression in vivo and that rhubarb can inhibit the P450 family through antimutation actions.35 DNA microarray analysis indicated that in tissues with MC, CYP3A4 expression was significantly decreased compared with that in normal tissue

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used TurboID to identify tissue-specific centrosome components in Caenorhabditis elegans and successfully detected interactions between the stable-associated component SPD-5 and the dynamically localized component Polo-like kinase 1 (PLK-1)

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In addition, both MSCs and HGF stimulated the development of neurons and the proliferation and migration of myelinating oligodendrocytes (OLs), reduced pro-inflammatory cytokines, and enhanced anti-inflammatory cytokines

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these data highlight the potential eminent role of ROS modulation in anticancer combinatorial therapies 162,163

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