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Rodent studies showed thyroid C-cell tumours at high doses, but human trials have not demonstrated increased thyroid cancer incidence over follow-up periods of 25 years

Circulating trimethylamine-N-oxide and risk of all-cause and cardiovascular mortality in patients with chronic kidney disease: a systematic review and meta-analysis

doi:10.1002/0471264180.or017.03

Lighter Periods: Heavy periods are common in women with a higher body weight

Gadanec et al., 2021)

The progression continues with increases occurring approximately every four weeks, moving from 0.5 mg to 1.0 mg, then to 1.7 mg, and finally to 2.4 mg for most patients