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Causal association of education, smoking, sedentary lifestyle and body mass index with disc degeneration: Mendelian randomization

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Although significant progress in the development of immunotherapy over the past two decades (2), approximately 50% of IBD patients show response failure after initial advanced therapies, with response rates exhibiting a further decline for second- and third-line treatments (3, 4)

What is intervertebral disc degeneration, and what causes it