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Acknowledgements This study received funding support from Grants-in-Aid for Scientific Research (A, JP19H01055

and C.W., 82203156 to S.Z., 824B2085 to Liang Zhu), the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences (2025-I2M-KJ-003, 2025-I2M-XHZY-016, 2025-I2M-GCC-002 and 2023-I2M-2-004 to C.W.), the National Key Research and Development Program of China (2023YFC3503200 to S.Z), the National High Level Hospital Clinical Research Funding (2025-LYZX-D-B04 to D.L., 2025-LYZX-C-B01 to C.W)