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The oral daily dose far exceeds the vitamin requirement because the normal transporter protein-mediated absorption is absent, leaving only very inefficient intestinal passive absorption

For example, did you have any numbness, loss of coordination, extreme tiredness, weakness, or muscle stiffness

You should also stick to the same time and day each week for the best effect

The inflammatory cascade also promotes angiogenesis (new blood vessel formation) and nerve sprouting, contributing to the progressive nature of endometriosis symptoms

It's regulated under DSHEA, not the FDA drug approval pathway

Without medical supervision Split dosing is off-label