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The Importance of Murine Models in Determining In Vivo Pharmacokinetics, Safety, and Efficacy in Antimalarial Drug Discovery

These peptides work through similar mechanisms, and combining them creates redundancy rather than synergy while potentially increasing side effects

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Elevated PAR levels induce oxidative stress, or photooxidation, where the over-accumulation of Fd, a strong reductant, readily reduces oxygen molecules, producing superoxide and peroxide radicals that can damage biological molecules (Latifi et al., 2009)