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The repair signature is reminiscent of the copper signature very recently demonstrated in regulatory T cells, whose energetic and functional phenotype is highly dependent on free intracellular copper

Clinical studies have shown significant weight loss may be achieved with these medications, although the amount of weight lost can vary depending on the medication, dose and individual

Clinical evaluations of participants were repeated on days 7, 14, and 21

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Our experimental design and modeling results, which considered smooth continuous gradient stimuli, carry such stimulus history, and with few assumptions, our model is mathematically analogous to the adaptivethreshold model (A detailed mathematical derivation is found in Appendix Note S1 part 5)

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