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in the Journal of Pharmacology and Experimental Therapeutics (which established Dihexas HGF/c-Met mechanism via Morris water maze rescue with HGF antagonist blockade) was the subject of an Expression of Concern in 2021 and was formally retracted in April 2025 by the publishing journal following investigation into image manipulation

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Discontinue use and consult a healthcare provider if you experience: Severe allergic reactions (rash, difficulty breathing, swelling), persistent injection site infections, or any concerning symptoms that do not resolve

- Mechanism: Orforglipron stimulates the GLP-1 receptor, increasing insulin secretion, reducing glucagon, slowing stomach emptying, and affecting appetite centers in the brain