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doi:10.1073/pnas.0730817100 ^ Jelakovic S., Kopriva S., Sss K-H, Schulz G.E

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While the size difference between tripeptides and heptapeptides (e.g., CyRL-QN15) may appear modest in terms of amino acid count, this difference may significantly influence their structural complexity, biological activity, and interaction with cellular targets

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This is likely because sermorelin cannot result in an excessively high rise in serum GH or IGF-1 concentrations, in contrast to GH therapy [29]