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Use caution and individualize the dosage and administration based on the patient's age, weight, and medical condition
It can improve hormone levels
But it does not work
Clinical trials have demonstrated substantial glycemic control improvements and weight loss averaging 15-21% of body weight at higher doses
Nat Rev Drug Discov 19:673694 Smith RA, Miller TM, Yamanaka K et al (2006) Antisense oligonucleotide therapy for neurodegenerative disease
Discussion 1) The goal of the research team of McCoy et al was to find an AngIV analog capable of permeating the blood brain barrier and eliciting procognitive activity by improving the metabolic stability of the tri- and tetrapeptide N-terminals of AngIV analogs
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