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The gradual titration schedule exists specifically to minimize this

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In a smaller pilot study, investigators measured coronary artery calcium using electron-beam computed tomography to assess the effect of supplementation with aged garlic extract on the progression of atherosclerosis in 19 adults already taking HMG-CoA reductase inhibitors (lipid-lowering drugs also known as statins) (18)

The conjugates formed are usually excreted from the cell and, in the case of the liver they are excreted in the bile

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