The Phase 2 clinical trial showed approximately 2-3 kg of additional fat loss compared to placebo over 12 weeks
PMID: 40544433) is potentially the most impactful obesity trial since the original STEP and SURMOUNT programs
Lifestyle modifications that may help include wearing loose, soft-textured clothing made from natural fibers, using silk or satin bedsheets that produce less friction, maintaining a consistent room temperature to avoid thermal triggers, practicing stress reduction techniques since psychological stress can amplify central sensitization, and optimizing sleep hygiene since poor sleep worsens pain perception
The most common side effect is irritation where the patch is applied
Storage after reconstitution Reconstituted intranasal retatrutide requires refrigeration at 2-8 degrees Celsius, similar to injectable retatrutide storage requirements
Ren Y, Wang K, Wu Y, Li J, Ma J, Wang L, Zhang C, Li J, Wei Y, Yang Y