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Gopal Grandhige, MD, FACS, Board-Certified Surgeon Last Reviewed: March 18, 2026 A hiatal hernia doesnt directly cause COPD, but the two conditions share a significant relationship that can worsen symptoms of both

An imbalance between the production of free radicals and the antioxidant defense systemcommonly observed in conditions such as postmenopausal estrogen deficiency, long-term glucocorticoid use, and agingis known as oxidative stress

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[2] This whole process may be regulated by a negative feedback mechanism, which may nullify any ancillary impacts of excess GH production