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This finding was consistent with the marked reduction in liver degeneration observed in the combination therapy group at the same time point (Fig

those with renal, hepatic, cardiac or respiratory disease

Irisin-loaded bone marrow mesenchymal stem cell-derived exosomes significantly downregulated the expression of Yes-associated protein (YAP), early growth response 1 (EGR1), and ACSL4, inhibited activation of the YAP/EGR1/ACSL4 signaling pathway, significantly increased GSH levels, decreased levels of Fe 2+ , lactate dehydrogenase (LDH), MDA, and lipid ROS, inhibited neuronal ferroptosis and lipid peroxidation, thereby ameliorating oxygen-glucose deprivation and reoxygenation (OGD/R)-induced neuronal injury

(2024a)

The fibroblasts also produce growth factors, substances that are essential in the process of skin healing