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There are some potential biases in these data that we need to be cautious about, but this gives us some valuable insights about the risk profile of these agents that can inform subsequent studies perhaps even a randomized controlled trial that can tease out the specific mechanisms and provide more conclusive evidence. Reduced risk overall GLP-1 receptor agonists have been approved in the United States to treat diabetes since 2005 and obesity since 2014
We found that KAT6A was required for normal levels of histone H3 lysine 23 acetylation (H3K23ac) in human cells and mouse brain
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