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Semaglutide mainly impacts blood sugar and appetite regulation, not sex hormones
These trials have targeted various groups, including individuals with diabetes, focusing on cognitive effects, and those with or at risk of AD or PD (summarized in Table 2 for AD and Table 3 for PD)
One can see that GSH production is complicated and can be limited
Another limitation of our study is the absence of a control group
Previous studies have found that ACSL4 catalyzes the activation of AA to AA-CoA, which can be utilized to generate 5-hydroxyeicosatetraenoic acid (5-HETE) by lipoxygenase (LOX), thus inducing ferroptosis via 5-HETE-mediated lipotoxicity [135]
