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The systemic anti-inflammatory effects observed after varicocele ligation may be attributed to a reduction in the production of anti-sperm antibodies (ASAs) and pro-inflammatory cytokines that are often elevated in patients with varicocele, thereby restoring the delicate balance necessary for optimal reproductive function ( In summary, the systemic anti-inflammatory effects of varicocele ligation surgery underscore the importance of addressing this condition not only to improve fertility outcomes but also to enhance overall male reproductive health

DSIP administration was placebo-controlled for 7 consecutive nights

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They are not FDA-approved finished products

Conducting meta-analyses in R with the metafor package

Dutta D et al