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Additionally, a large meta-analysis of 94,885 patients with Medicare demonstrated a 37% reduction in mortality 4 years after bariatric surgery with benefits evident in males and females as well as individuals with and without a pre-surgical diagnosis of diabetes [22]

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While this use is off-label, the mechanistic rationale is sound and the early data is encouraging

Low doses of GHB can cause nausea, while high doses can lead to: Unconsciousness Seizures Slowed heart rate Considerably slowed breathing Lower body temperature Vomiting Nausea Coma Death Alcohol worsens all of these symptoms and it can lead to an overdose

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Efficacy and safety studies are equally important for the successful development of such delivery systems