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A subset of CD8 T cells also express GLP-1R when exhausted

The practical result is a compound that reduces energy intake through appetite suppression while simultaneously increasing energy expenditure

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Lastly, EX-4 enhances cognitive function in APPxPS1-Ki AD mice by improving short- and long-term memory and increasing brain lactate levels, indicating a shift toward anaerobic glycolysis

Bakris G, Agiro A, Mu F, Cook EE, Greatsinger A, Sundar M, et al

GLP-1s work by mimicking natural hormones that regulate hunger, slow digestion, and help control blood sugar