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Although the mechanism is not clear, research in animals suggests that riboflavin deficiency may impair iron absorption, increase intestinal loss of iron, and/or impair iron utilization for the synthesis of hemoglobin (16)

In particular, glutathione (GSH) depletion is a common feature of apoptotic cell death triggered by a wide variety of stimuli including activation of death receptors, stress, environmental agents, and cytotoxic drugs

It bypasses the pancreas entirely

Research resource: small RNA-seq of human granulosa cells reveals MiRNAs in FSHR and aromatase genes

Key considerations for clinical use include its unapproved status and the unregulated supplement market

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