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For people with T2D, survodutide 1.8 mg twice weekly resulted in 9% WL vs

Hypertriglyceridemia and hyperinsulinemia are potent inducers of endothelin-1 release in humans

Statins may trigger muscle side effects by activating inflammatory danger signals The relatively recent development and introduction of GLP-1RA (glucagon-like peptide-1 receptor agonist) drugs like semaglutide and dual agonists like tirzepatide have provided an unprecedented pharmacological solution to unwanted weight gain, with documented weight reductions of 12-19% in non-diabetic patients

But further research is required to fully understand the links between the gut microbiota and cardiovascular disease, as well as the underlying mechanisms, offering fresh ideas and approaches for the treatment of cardiovascular disease

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