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Because glucagon-receptor agonism could theoretically raise glucose, the phase 2 program specifically examined participants with type 2 diabetes and found that retatrutide lowered HbA1c rather than raising it evidence that the molecules GLP-1 and GIP activity more than offsets any glucagon-driven glucose elevation

PMID: 25

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However, based on current research, retatrutide may be a good fit for those who: Are obese or overweight Have type 2 diabetes Live with fatty liver disease Have high blood pressure Have sleep apnea She adds it may not be a good fit for those with: A history of pancreatitis Certain thyroid cancers (such as medullary thyroid carcinoma) Specific digestive conditions (such as severe gastroparesis) People who are pregnant or breastfeeding Similar to many medications, retatrutide is not without side effects

What does the combination add compared with the individual molecules