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Pre-existing Metabolic Conditions Hypothyroidism, PCOS, insulin resistance, previous metabolic adaptation from yo-yo dieting all reduce response to treatment
Methods Using a subset of Truveta Data, we identified patients with any medication dispense (e.g., medication fill) of a GLP-1 RA (semaglutide AOM, semaglutide ADM oral, semaglutide ADM injectable, liraglutide ADM, exenatide ADM, lixisenatide ADM, tirzepatide ADM, and dulaglutide ADM) between January 2018 and October 2023
Some people get side effects, especially at the start
Peptide therapy with PT-141 does not force a physical response
But the trajectory matters more than today's number
Intensive glycaemic control and cancer risk in type 2 diabetes: a meta-analysis of major trials
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