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Further subgroup analyses based on the dosage and duration of treatment also demonstrated no significant SMD in any subgroups (Supplementary Figure 1)

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Unlike earlier secretagogues with broader endocrine activity, Ipamorelin demonstrates a high degree of selectivity for GHSR-1a, allowing researchers to examine ghrelin-mediated intracellular pathways with reduced interference from parallel pituitary hormone systems (5)

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The newly identified Family DY (C1198c) had a later onset with predominantly gastrointestinal and laryngeal involvement