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Notably, earlier alanine substitution studies have revealed that Y 152 , R 190 , K 197 , L 201 , R 299 , N 300 , W 306 , R 310 , I 313 , E 364 , L 384 , L 388 of GLP-1R are the most important residues for GLP-1 binding affinity and potency
Eluted fractions consisting of receptor and G-protein complex were pooled and concentrated to 3-5 mg/mL
Side effects Most common: nausea, vomiting, diarrhea, constipation, decreased appetite, abdominal discomfort, fatigue, and injection-site reactions
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