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GLR3.3 is required for GSH-triggered systemic [Ca 2+ ] cyt propagation GLR proteins which generally contain an amino-terminal domain (ATD), a ligand-binding domain (LBD), a transmembrane domain (TMD), and a carboxyl-terminal domain (CTD), have broad agonist profiles including glycine, cysteine, methionine, Glu and GSH 29,30,31,32