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The weight regain reality Clinical trial data is clear: most people regain a significant portion of lost weight after discontinuing GLP-1 therapy
PMID: 24932808
A good metric to consider is this: If an obese patient (BMI 30 to 34.9) is on a GLP-1 for six months and has not reached 10% TBWL, they should be referred back to their primary care provider to reassess their weight-loss plan
Consensus Clinical Guide, June 2024
Neither structure is inherently better - it depends on whether you'd rather pay separately for FDA-approved brand medication, subject to provider determination and availability, or pay one bundled fee that may include a compounded formulation
The consequences extend far beyond weight gain
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