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Additionally, a higher proportion of participants in the semaglutide group achieved weight loss of 5% or more (86.4% vs
66 While BiP and GRP94 regulate the switch from pro-folding to pro-degradation, 44 GRP94 maintains the solubility of aggregation-prone proteins to enable their translocation into the cytoplasm, 67,68 although GRP94 has a weaker interaction with the ERAD machinery than BiP does
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