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As such, the model was used to simulate how long it would take pharmacologically and toxicologically relevant concentrations of doxorubicin to yield a 70% reduction in GSH concentration, indicative of impaired cellular antioxidant defence, protein binding and cell death 19
4 AtkinsonD
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NNMT Inhibition Mechanism The compound's activity centres on blocking NNMT, found in various tissues including adipose
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