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Third, our analysis did not include costs from the informal healthcare sector (e.g., transportation costs) and from the non-healthcare sector (e.g., lost productivity for individuals) due to data unavailability, and thus the results of this study may not be extrapolated to a societal perspective

Final Verdict: Worth It for Some, Dangerous for Others The GLP-1 revolution is real, and for some patientsparticularly those with type 2 diabetes and obesity-related cardiovascular diseasethese medications represent a genuine breakthrough

They improve glycemic control through several mechanisms: Increasing insulin secretion from pancreatic beta cells in a glucose-dependent manner Suppressing inappropriately high glucagon secretion Slowing gastric emptying which stabilizes blood glucose excursions Supporting beta cell proliferation to help preserve insulin production over time Reducing appetite and calorie intake leading to weight loss In patients with type 2 diabetes not meeting glycemic targets on other oral medications like metformin, adding a GLP-1 drug allows many to achieve hemoglobin A1c reductions of 0.7-1.6%.(40) This significantly improves diabetes control and lowers risks of long-term vascular complications

Aim for around 30 grams (g) of protein at each meal and about 25 to 30 g of fiber per day (the best sources are fruits, veggies, and whole grains)

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