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The translational meaning for an exogenous TB-500 fragment in humans is unknown, but it is the most-cited theoretical risk in clinician reviews of this stack and is one reason researchers exclude individuals with active or undiagnosed cancer from any informal protocol

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It's a synthetic version of a naturally occurring peptide found in the human gastrointestinal system

Here is the caveat that most consumer articles omit: the tripeptide in that landmark study was AHK-Cu L-alanyl-L-histidyl-L-lysine copper, sometimes labeled copper tripeptide-3 not GHK-Cu

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None of the combination-specific risks have been characterized in a human trial because that trial does not exist