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Carnitine supplement intervention and sample collection in the healthy study cohort A total of 56 healthy volunteers, comprising 33 omnivores and 23 vegetarians, were recruited to receive 500 mg of oral supplementation of carnitine fumarate (GNC) daily (equals to 23-fold of carnitine obtained from regular diet) for 1 month

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A key concept for understanding this interface is that while health-damaging behaviors (e.g.: poor diet, excessive alcohol consumption, sleep deprivation and circadian disruption) contribute to allostatic load and the many consequences of such behaviors on triggering and exacerbating these illnesses, it is increasingly recognized that health-promoting behaviors that protect mitochondrial metabolism and energy regulation are an essential component of successful allostasis

Absence of these alterations in substance-treated animals suggests homeostatic and anti-inflammatory effects preventing cardiovascular neuropathy progression, potentially through NF-B inactivation (Rastgoo et al., 2023)

Current treatments are largely palliative and do not address the underlying fibrosis