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A 2020 meta-analysis of 37 randomized controlled trials with over 2,200 participants found that L-carnitine supplementation led to an average weight loss of 1.21 kg, a slight drop in BMI, and a reduction in fat mass by about 2.08 kg, especially in people with overweight or obesity

Humans have not shown the same risk, but people with a family history of thyroid cancer or MEN 2 (a rare condition) should avoid these drugs

Admittedly, these metabolic analyses were focused on the initial phase of treatments, as this period displayed the largest changes in body weight and is less likely affected by compensatory responses, which might confound the identification of primary mechanisms

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Drinking less than usual is advisable