Main limitation: selectivity figures (such as an in-vitro ~11.7-fold preference for senescent cells) come from cell models, not humans
Martnez-Reyes I, Cardona LR, Kong H, Vasan K, McElroy GS, Werner M, et al
This suggests that these hormones have pleiotropic effects beyond lowering blood glucose levels [9,10,11]
Taguchi N, Hata T, Kamiya E, Homma T, Kobayashi A, Aoki H
PubMed PMID: 39500933 De Souza Prestes A, Stefanello ST, Salman SM, Pazini AM, Schwab RS, Braga AL et al (2012) Antioxidant activity of -selenoamines and their capacity to mimic different enzymes
If cold is good, wouldn't colder be better