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The delayed release of Amarasate bitter extract in the upper duodenum stimulates the activation of TAS2R receptors on enteroendocrine cells to release GLP-1, CCK and PYY (appetite suppressing hormones)
The origin of these fat-reducing injectables can be traced to mesotherapy, developed in France in the 1950s by Dr Michel Pistor
10.1016/j.jhazmat.2013.01.004 J
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